Use of elexacaftor/tezacaftor/ivacaftor combination in pregnancy
G Cimino, S Sorrenti, M Murciano, P Galoppi… - Archives of Gynecology …, 2024 - Springer
G Cimino, S Sorrenti, M Murciano, P Galoppi, F Ascenzioni, B Botta, R Brunelli
Archives of Gynecology and Obstetrics, 2024•SpringerIntroduction Management of cystic fibrosis has recently stepped forward with the introduction
of cystic fibrosis transmembrane conductance regulator (CFTR) modulators, although data
on potential adverse effects are lacking for many categories of patients, such as pregnant
women. Methods We report one of the first reports on the outcome of pregnancy in a woman
treated with Elexacaftor/Tezacaftor/Ivacaftor during the second and third trimester of
pregnancy, showing a significant improvement of respiratory status, compared with the first …
of cystic fibrosis transmembrane conductance regulator (CFTR) modulators, although data
on potential adverse effects are lacking for many categories of patients, such as pregnant
women. Methods We report one of the first reports on the outcome of pregnancy in a woman
treated with Elexacaftor/Tezacaftor/Ivacaftor during the second and third trimester of
pregnancy, showing a significant improvement of respiratory status, compared with the first …
Introduction
Management of cystic fibrosis has recently stepped forward with the introduction of cystic fibrosis transmembrane conductance regulator (CFTR) modulators, although data on potential adverse effects are lacking for many categories of patients, such as pregnant women.
Methods
We report one of the first reports on the outcome of pregnancy in a woman treated with Elexacaftor/Tezacaftor/Ivacaftor during the second and third trimester of pregnancy, showing a significant improvement of respiratory status, compared with the first trimester when the medication was discontinued due to unknown and, therefore, potential teratogenic effects. Also, we performed the review of the existing literature on the topic.
Results
The course of pregnancy was uneventful, with reference to major obstetric complications, and the patient delivered a healthy neonate. These results were similar to those coming from other short series of pregnant women affected by cystic fibrosis and treated with CFTR modulators during pregnancy.
Conclusions
Thus, despite the lack of evidence on the topic, the use of Elexacaftor/Tezacaftor/Ivacaftor in pregnancy seems to be apparently not associated with major adverse events, thus opening optimistic scenarios in terms of management of these patients.
Springer
