Transfer across perfused human placenta. III. Effect of chain length on transfer of free fatty acids
J Dancis, V Jansen, HJ Kayden, L Bjornson… - Pediatric Research, 1974 - nature.com
J Dancis, V Jansen, HJ Kayden, L Bjornson, M Levitz
Pediatric Research, 1974•nature.comExtract: Human placentas were perfused in vitro with straight chain, even-numbered free
fatty acids (FFA) and the transfer rates from maternal to fetal circulation were measured. The
transfer rates increased logarithmically as chain length decreased. The clearances,
calculated as percentage of clearance of antipyrine were: palmitic acid, 4%; myristic acid,
10%; lauric acid, 16%; decanoic acid, 18%; octanoic acid, 50%; hexanoic acid, 64%.
Speculation: Transfer of hydrophobic materials through the placenta is a complex process …
fatty acids (FFA) and the transfer rates from maternal to fetal circulation were measured. The
transfer rates increased logarithmically as chain length decreased. The clearances,
calculated as percentage of clearance of antipyrine were: palmitic acid, 4%; myristic acid,
10%; lauric acid, 16%; decanoic acid, 18%; octanoic acid, 50%; hexanoic acid, 64%.
Speculation: Transfer of hydrophobic materials through the placenta is a complex process …
Abstract
Extract: Human placentas were perfused in vitro with straight chain, even-numbered free fatty acids (FFA) and the transfer rates from maternal to fetal circulation were measured. The transfer rates increased logarithmically as chain length decreased. The clearances, calculated as percentage of clearance of antipyrine were: palmitic acid, 4%; myristic acid, 10%; lauric acid, 16%; decanoic acid, 18%; octanoic acid, 50%; hexanoic acid, 64%.
Speculation: Transfer of hydrophobic materials through the placenta is a complex process which is probably affected by many factors. The present studies with FFA suggest that, for these compounds, protein binding may be particularly significant. If so, it may affect transfer rate by influencing release from maternal serum albumin, diffusion through the placenta, and uptake by fetal plasma. These several factors require further analysis.
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